Heme-regulated Inhibitor (hri) Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 (eif2) Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure
نویسندگان
چکیده
HEME-REGULATED INHIBITOR (HRI) KINASE-MEDIATED PHOSPHORYLATION OF EUKARYOTIC TRANSLATION INITIATION FACTOR 2 (EIF2) INHIBITS TRANSLATION, INDUCES STRESS GRANULE FORMATION, AND MEDIATES SURVIVAL UPON ARSENITE EXPOSURE. Edward McEwen#, Nancy Kedersha, Benbo Song#, Donalyn Scheuner#, Natalie Gilks, Anping Han^, Jane-Jane Chen^, Paul Anderson and Randal J. Kaufman#* From: # Howard Hughes Medical Institute and the *Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115; ^ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139. Running Title: HRI mediates translational control in response to arsenite. Address correspondence to: Randal J. Kaufman, Howard Hughes Medical Institute and the *Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, Tel. 734-763-9037; Fax: 734-763-9323 ; E-Mail: [email protected]
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